The accident occurred in the Nolchata area near Arikhola Rail Station around 10:30 am on Saturday.
The dead have yet to be identified.
The Egarosindhu train was headed from Kishoreganj to Dhaka when it crashed head-on into a pickup van carrying palm fruit from Nagri at a rail crossing, said Arikhol Station Master Kamrul Islam.
Three passengers on the pickup van were killed on the spot.
Nagri-Nolchata rail service was suspended for nearly an hour after an accident, but is now back to normal, said Station Master Kamrul.
